Author

Mengyuan Zhang

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Open access Sep 2026

A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan

Brain aging is a major risk factor for cerebrovascular and neurodegenerative diseases, yet continuous cell-type changes across the human lifespan remain incompletely defined. Here, we integrate 15 prefrontal cortex (PFC) snRNA-seq datasets from 158 neurologically healthy donors (19–101 years) to construct an atlas of...

Rui-Ze Niu, Meng-Yuan Zhang, Zhi-Lan Yang et al. · npj Aging · 0 citations

Open access Aug 2026

GWAS-Informed Candidate Genetic Variants and Gene–Gene/Gene–Environment Interaction Patterns Associated with Intervertebral Disc Degeneration: A Chinese Han Case–Control Study

Background/Objectives: Intervertebral disc degeneration (IDD) is a multifactorial spinal degenerative condition influenced by inherited susceptibility and environmental exposures. Genetic evidence from Chinese Han populations remains limited. This study aimed to evaluate GWAS-informed and previously reported candidate...

Ridan Lei, Mengyuan Zhang, Man-Jun Luo et al. · Genes · 0 citations