ASB3 limits adipocyte thermogenesis and energy expenditure through p62 ubiquitination.
BACKGROUND Adipose thermogenesis increases energy expenditure and protects against obesity. However, the endogenous mechanisms that restrain this process are not fully understood. METHODS Adipose tissue- and adipocyte-specific Asb3-deficient mice were exposed to cold or treated with the β3-adrenergic receptor agonist...