The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...
Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al.· bioRxiv· 0 citations
ABSTRACT Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000–2022) using pseudovirus-based neutralization assays and antigenic cartogra...
Yi-Meng An, Mei-Na Cai, Chen-Yan Zhao et al.· Emerging Microbes and Infect...· 0 citations
The successfully developed novel 6-9ΔGΔ51+S226R-H5N1 vaccine candidate not only exhibits excellent safety and immunogenicity but also represents a powerful potential tool for the effective prevention and control of highly pathogenic avian influenza.
Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al.· Signal Transduction and Targ...· 0 citations
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