KRAS gene mutations represent one of the most common drivers of human cancers, with particularly high prevalence in pancreatic, lung, and colorectal cancers. Among these, the KRASG12D mutation has long been considered an "undruggable" target because of its unique structural characteristics. This article systematically...
Abstract Self-assembled nanosystems based on non-covalent interactions of traditional Chinese medicine (TCM) monomers have attracted extensive attention in drug delivery. In direct carrier-free systems, the active molecules also serve as building units. These systems may reduce the need for extra carriers and provide h...
Xin-Rong Wu, Hui-Min Liu, Tian-Jiao Niu et al.· International Journal of Nan...· 0 citations
The escalating global burden of metabolic diseases including obesity, type 2 diabetes, and metabolic dysfunction-associated fatty liver disease (MAFLD)-highlights an urgent need to identify new therapeutic targets. Although elevated hepatic de novo lipogenesis (DNL) is a hallmark of metabolic dysfunction, targeting i...
Wei Wang, Hui Wang, Yi-Han Liu et al.· Cell Death Discovery· 0 citations
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