Open access
Sep 2026
Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution
ABSTRACT Enzyme turnover number (kcat) is a central kinetic parameter for biocatalysis, but experimental determination is low‐throughput and existing computational methods inadequately model enzyme–reaction interplay. Here, we introduced MCKcat, a deep learning framework that integrates multi‐scale convolutional featur...
Feng-Ya Ge, Xiang-Yang Ma, Ji-Yan Li et al.
· Advancement of science · 0 citations