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Meng-Nan Zhang

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Open access Sep 2026

YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.

It is demonstrated that increased matrix stiffness activates YAP/TEAD4-dependent transcriptional program and promotes ATP1A1 expression, thereby converting mechanical cues into chemical signaling output and finally promoting malignant phenotypes in the tumor.

Meng-Nan Zhang, Xin-Peng Wen, Jingyi Liu et al. · 0 citations

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