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Open access Sep 2026

Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice.

Two TREM2-activating single-domain antibodies, 10C11 and 10E12, activate microglia and rescue cognitive deficits in early-stage transgenic mice with five familial Alzheimer's disease mutations (5×FAD) following ventral hippocampal injection are presented.

Xiao-Xiao Yu, Qiao-Yun Ren, Yan-Chun Gao et al. · 0 citations

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