161Tb Radiopharmaceutical Therapy as a Treatment for RANKL-Positive Multiple Myeloma.
BACKGROUND Denosumab, an anti-RANKL monoclonal antibody, is clinically approved for bone protection in multiple myeloma (MM) but lacks direct cytotoxic effects on tumor cells. Herein, we repurpose this well-tolerated antibody as a targeted delivery vehicle by conjugating it with the emerging radionuclide 161Tb, which e...