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Meng-Jiao Lan

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Open access Sep 2026

α-Herpesviruses exploit host ssDNA gap prevention pathways for GC-rich genome replication and reactivation.

Many α-herpesviruses, such as herpes simplex virus type 1 (HSV-1) and pseudorabies virus, possess GC-rich genomes prone to forming G-quadruplex (G4) structures. However, the impact of these G4 structures on viral genome maintenance is unknown. Here, we demonstrate that G4s impede lagging strand DNA synthesis in the vir...

Juan Zhang, Meng-Jiao Lan, Hui-Guo Fu et al. · 0 citations

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