Standardization of the endpoint PCR for identification of β-globin gene haplotypes associated with sickle cell anemia in Neonatal Screening patients, Panama.
Sickle cell anemia is an inherited hemoglobinopathy characterized by the presence of hemoglobin S (HbS), which is estimated to affect approximately 0.04% of the Panamanian population. Its clinical severity is modulated by the haplotypes of the β-globin gene—Benin, Bantu, Senegal, Cameroon, and Arab-Hindu—whose characte...