Platelet-erythrocyte complex production is exacerbated by histones and protected by small polyanion histone neutralizing compounds.
Platelet-erythrocyte (PE) complexes, composed of single erythrocytes bound to platelets, are a physiological component of the bloodstream and contribute to erythrocyte turnover. Conditions in which PE complex production is increased or their clearance from the circulation is impeded are associated with hypercoagulable...