Author

Melanie Nufer

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Open access Sep 2026

Integrated analysis of hematopoietic changes following heterochronic bone marrow transplantation between young and aged mice.

BACKGROUND aging is a multifactorial process characterized by progressive loss of tissue homeostasis and regenerative capacity, with haematopoiesis being profoundly affected. Age-associated changes in hematopoietic stem cells (HSCs) include increased frequency but reduced function, impaired self-renewal, and myeloid bi...

J. A. Bejarano-García, Melanie Nufer, Rocío Caracuel et al. · Transplantation and Cellular... · 0 citations

Open access Jul 2026

Fatty-acid-based antimiR-23b delivery in the DMSXL model: A potential therapeutic strategy for brain dysfunction in myotonic dystrophy type 1

This study evaluates the therapeutic potential of the lipid-conjugated antimiR-23b, X82108, designed to promote MBNL1/2 upregulation through inhibition of miR-23b, and highlights X82108 as a promising systemic therapy for DM1.

D. Piqueras-Losilla, Andrea García-Rey, Aline Huguet-Lachon et al. · Cell Reports Medicine · 0 citations