Aug 2026
Engineered α-Synuclein-specific nanobody CAR iTregs restrain neuroinflammation and proteinopathy in Parkinson’s disease mice
It is demonstrated that αSyn-specific CAR iTregs can selectively exert potent local immunomodulatory effects, establishing a promising antigen-specific cellular immunotherapy platform for PD and other synucleinopathies.
Alice Calderoni, Melania Nannoni, Giorgia Ruffini et al.
· bioRxiv · 0 citations