Immune checkpoint inhibitors combined with VEGF/VEGFR-targeted therapy in microsatellite-stable advanced colorectal cancer: clinical advances and the potential for immune-sensitive tumor conversion
Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality worldwide, and mismatch repair-proficient/microsatellite-stable (pMMR/MSS) tumors account for the majority of metastatic CRC cases. In contrast to dMMR/MSI-H CRC, pMMR/MSS tumors are typically characterized by low immunogenicity, li...