Summary Heart failure (HF) is a multisystem syndrome in which myocardial dysfunction is shaped by metabolic, vascular, and extracardiac abnormalities. Across HFrEF and HFpEF, impaired substrate utilization, mitochondrial function, endothelial signaling, coronary microvascular function, and mechano-energetic coupling di...
This review systematically summarizes the molecular mechanisms by which non-coding RNAs regulate the core components of PANoptosis and its upstream signaling pathways, providing a theoretical basis for understanding the interactive logic of cell death networks and for developing precise interventions for related diseas...