Mei-Chen Yeh

Sexual dimorphism in high-fat diet-induced depression-like phenotypes in mice: astrocyte-centered molecular, circuit, and microbiota associations.

Metabolic disorders (MetD) are linked to depression, both of which exhibit sex differences in prevalence and clinical presentation; however, the mechanisms underlying sex-specific vulnerability to MetD-related depression remain unclear. Male and female C57BL/6 N mice were fed a high-fat diet (HFD) for 12 weeks (8 to 20...