The principal organs involved in the control of mineral homeostasis are the kidneys, parathyroid glands, intestine and bone, which interact in a finely coordinated manner to maintain calcium and phosphorus levels. Mineral balance is disrupted in the context of chronic kidney disease (CKD), triggering compensatory mec...
Juan Miguel Diaz-Tocados, Juan Diego Domínguez-Coral, M. D. de Borst et al.· Clinical Kidney Journal· 0 citations
Aldosterone, the terminal effector of the renin-angiotensin-aldosterone system, regulates sodium retention, potassium excretion, and blood pressure. Beyond these classical effects, aldosterone-associated and mineralocorticoid receptor (MR)-mediated signaling is implicated in inflammation, oxidative stress, fibrosis, al...
Mehmet Kanbay, Rama Al-Shiab, Ermeena Shah et al.· Nephrology, Dialysis and Tra...· 0 citations
BACKGROUND AND AIMS
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular and kidney outcomes, but their effects on circulating inflammatory biomarkers remain uncertain. We systematically reviewed randomized evidence on the effects of SGLT2is on peripheral-blood inflammatory biomarkers.
METHODS
P...
Mehmet Kanbay, Ermeena Shah, Rama Al-Shiab et al.· Diabetes, obesity and metabo...· 0 citations
Investigating treatments for CKD possess anti-inflammatory properties that might contribute to their previously established clinical benefits, including renin-angiotensin-aldosterone system inhibitors, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists and non-steroidal mineralocortico...
Katherine R. Tuttle, Mehmet Kanbay, Radica Z. Alicic et al.· Nature Reviews Nephrology· 1 citation
Kidney imaging advances are transforming the field of nephrology by allowing non-invasive examination of renal structure, function, and pathology, and imaging biomarkers show significant predictive value for progression to kidney failure in CKD, including diabetic kidney disease, independent of traditional measurements...
Mustafa Guldan, Ibrahim Gulmaliyev, Rama Al-Shiab et al.· Clinical Kidney Journal· 0 citations
ABSTRACT Chronic kidney disease (CKD)-associated osteoporosis is present in approximately 25% of all patients with CKD. The occurrence increases as kidney function declines, with prevalences up to 75% in elderly dialysis patients. It is often undiagnosed due to the perception that limited treatment options are availabl...
Ditte Hansen, Hanne Skou-Jørgensen, Mehmet Kanbay et al.· Clinical Kidney Journal· 0 citations
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