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Author

Megan M. Shuey

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Open access Sep 2026

Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations

Sickle cell trait (SCT) is increasingly recognized as a risk factor for adverse health outcomes. We utilized three large US electronic health record-based biobanks (Vanderbilt University Medical Center’s BioVU, Penn Medicine Biobank, and All of Us) to conduct phenome-wide association (PheWAS) and clinical laboratory-wi...

M. Hysong, Megan M. Shuey, T. Miller-Fleming et al. · 0 citations
Open access Sep 2026

Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes

Summary Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the UK Biobank (...

H. Jandu, Ayo Olowofela, Megan M. Shuey et al. · 0 citations
Review Open access Aug 2026

Practical considerations for social determinant-based disease prediction in the All of Us research program

It is shown that requiring sufficient individual-level SDoH survey data results in significant selection bias and sample reduction in AoU, and that area-level SDoH metrics contribute to disease prediction independently of individual-level measures.

M. Hysong, A. Manning, Michael D. Green et al. · 1 citation

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