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McKinnon Walsh

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Sep 2026

Abstract A118: Leveraging metabolic restriction in cooperation with SHP2 deficiency to inhibit PDAC

SHP2 (Ptpn11) is a tyrosine phosphatase well defined by its role in the MAPK pathway, including modulation of KRAS activity. KRAS is mutated in >90% of Pancreatic Ductal Adenocarcinoma (PDAC), which is the third leading cause of US cancer deaths. Mutant KRAS drives uncontrolled cell proliferation and cancer growt...

McKinnon Walsh, Austin E. Eades, Bailey A. Bye et al. · 0 citations

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