Aβ17–22 Derived Hexapeptide Segment Inhibits Islet Amyloid Polypeptide (IAPP) Aggregation and Attenuates Cytotoxicity
Misfolding and aggregation of islet amyloid polypeptide (IAPP) are associated with the decline of β-cells in type 2 diabetes (T2D). Design of short peptide-based inhibitors of β-sheet-rich amyloid plaque formation is challenging due to the dynamic nature of the amyloid species. The key sequences involved in cross-amy...