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Mayukh Chakrabarti

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Open access Sep 2026

Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS

Direct targeting of KRAS through the Switch-II pocket is an effective therapeutic strategy, but acquired resistance limits clinical benefit. We examine clinically observed resistance mutations (R68S, H95Q, Y96C, Y96D and Q99L) arising during KRAS G12C inhibitor therapy using biochemical, structural, computational and...

M. J. Whitley, M. Dyba, Mayukh Chakrabarti et al. · 0 citations

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