Maximillian Golovsky

Efficient Myoinositol biosynthesis from glucose through gluconate bypass of glycolysis.

Microbial myo-inositol (MI) production typically requires deletion of conditionally essential genes such as phosphoglucose isomerase (pgi in E. coli) to increase pools of the precursor glucose-6-phosphate (G6P). This disrupts growth and has necessitated complex glycerol co-feeding strategies. Here, we address this limi...