Incorporation of a Hydrazone Base-Pair Analog as a Nucleic Acid Staple: Structure, Stability, Triggered Release, and Ligase Studies.
Hydrogen bonding and hydrophobic stacking are the primary interactions that control the structure and functionality of DNA systems, including those of most synthetic variants. These interactions are weak and are highly dynamic. Tunable Orthogonal Reversible Covalent (TORC) bonding utilizes dynamic covalent interactions...