Systematic In Silico Discovery of a Conserved Tubulin-Folding Chaperone Network in Plasmodium falciparum: Implications for Microtubule Homeostasis and Antimalarial Targeting
Microtubules constitute fundamental cytoskeletal polymers that orchestrate cell division, intracellular trafficking, and the maintenance of cellular architecture across eukaryotic lineages. The biogenesis, folding, and steady-state homeostasis of αβ-tubulin heterodimers are tightly regulated by an evolutionarily conser...