Genome-scale perturbation signatures from primary human CD4+ T cells improve genetics-based prioritization of immune drug targets
It is highlighted that perturbational signatures in the disease-relevant human cell type harbor target-relevant signals beyond human genetics, offering a generalizable route to indication-specific prioritization as perturbation atlases expand.
Alexander L. Han, Max Slotnik, David A. Fox et al.
· bioRxiv · 0 citations