Ferroptosis-Mediated Radiosensitization in Glioblastoma: Preclinical Insights and Translational Opportunities
Glioblastoma (GBM) remains the most common and most aggressive primary malignant brain tumor in adults, and despite maximal safe resection with adjuvant radiotherapy (RT) and temozolomide (TMZ), median overall survival remains 12–15 months with near-universal recurrence. Ferroptosis, an iron-dependent form of regulated...