Abstract. Kimmerle anomaly (KA) is one of the most common osseous anomalies of the craniovertebral junction and may lead to vertebrobasilar insufficiency and neurovascular complications. The aim of this study was to analyze the incidence of KA in a neurological hospital, to identify the main clinical syndromes, and to substantiate rational conservative treatment approaches. The study included a screening examination of 8,436 patients hospitalized in a neurological clinic over a six-year period, using clinical neurological assessment, radiography, CT, MRI, and ultrasound of cerebral and cervical vessels. KA was identified in 68 patients aged 18–67 years. Three major clinical syndromes were distinguished: pain syndrome, vascular insufficiency syndrome, and autonomic dysfunction syndrome, as well as three degrees of disease severity. Conservative therapy consisting of non-steroidal anti-inflammatory drugs, muscle relaxants, vitamin complexes, physical therapy, and massage proved effective in symptom control and achievement of long-term remission. The findings support the effectiveness of pathogenetically oriented conservative management of KA, particularly in early and moderate stages of the disease.
Abstract. Brain tumors remain a major cause of morbidity and mortality worldwide. High-field MRI is considered the gold standard for neuro-oncological diagnostics; however, its availability is limited in many regions. This study aimed to evaluate the diagnostic capabilities of a low-field 0.2 T MRI system in detecting and characterizing intracranial tumors and to compare the findings with CT data. A retrospective analysis of 14,570 brain examinations performed between 2000 and 2009 identified 678 space-occupying lesions (4.7%). Gliomas, metastases, and meningiomas were the most common tumors. Low-field MRI demonstrated high sensitivity in detecting tumor heterogeneity, cystic degeneration, necrosis, hemorrhage, and contrast enhancement patterns, which were critical for tumor grading. Dynamic contrast-enhanced MRI improved differentiation between benign and malignant tumors. The results indicate that low-field MRI is a valuable, cost-effective tool for neuro-oncological diagnostics, particularly in resource-limited settings.
A prospective multicenter comparative protocol was developed for adults with chronic cervical injury and neurological stability, and implanted brain–spine systems have enabled intention- driven standing and walking in an individual with chronic tetraplegia, whereas non-invasive cervical stimulation combined with task practice has improved hand strength and sensation in cohorts.
A multicenter crossover study is proposed for adults with levodopa-responsive Parkinson’s disease and motor fluctuations despite optimized conventional stimulation, which combines blinded motor-state improvement with reduced troublesome dyskinesia and off time.
