PURPOSE OF REVIEW
To cover recent work on fundamental immunological mechanisms and strategies to elicit successful priming and boosting of B cells in HIV vaccine efforts.
RECENT FINDINGS
HIV vaccine research has reached substantial milestones in recent years, showing successful priming and early boosting of desired p...
Kristy M. Waldrep, Mauricio V. Padilla, Robert K. Abbott· Current Opinion in HIV and A...· 0 citations
The protective benefits of vaccination can critically depend on the durability of the corresponding immune response. However, the factors influencing vaccine durability are poorly understood. Here, we tested whether antigen avidity (i.e., cumulative multivalent binding strength) affected the durability, magnitude, and...
Nicole G Weidner, Mauricio V. Padilla, Layne Pruitt et al.· Science Translational Medici...· 3 citations
Vaccination with real-world complex antigens often elicits a hierarchical immune response to different epitopes. This immunodominance is a major obstacle in vaccine design because nonprotective epitopes often divert the immune response away from protective epitopes. We posited that B cell epitope avidity (i.e., total m...
Mauricio V. Padilla, Nicole G Weidner, Layne Pruitt et al.· Science Translational Medici...· 3 citations
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