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Author

Maureen A. Kane

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Aug 2026

Proteolysis Targeting Chimera (PROTAC) Linkerology Enhances the CDK-Degradation Selectivity Profile of a Multi-CDK Inhibitor: Discovery of Potent, Anti-Leukemic CDK9 Degraders.

The degradation efficiency of a PROTACbivalent compounds that link together a ligand for a protein of interest with a ligand for an E3 ligaseis governed, in part, by the length and flexibility of its linker ("linkerology"), as well as the accessibility of ubiquitinatable surface lysines. Based on the prior serendipit...

Alexandria M. Chan, Christian Eberly, Christopher C. Goodis et al. · 0 citations
Open access Jul 2026

Formulation and assessment of long-acting pharmaceutical co-formulated crystals.

This work investigates solvent/anti-solvent crystallization as a simple and versatile method for producing single‑drug as well as co‑formulated crystalline depots using curcumin and piperine as a model system and demonstrates that the solvent/anti-solvent ratio strongly modulates crystal properties and accelerated rele...

Jamie L. Hernandez, Neeti R. Prasad, J. Daniel et al. · 0 citations

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