Author

Mattias F. Lindberg

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Open access Sep 2026

Network modeling predicts how DYRK1A inhibition promotes cardiomyocyte cycling after ischemic/reperfusion injury.

The adult mammalian heart has a limited ability to regenerate lost myocardium following myocardial infarction (MI), largely due to the poor proliferative capacity of cardiomyocytes (CMs). Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a known regulator of cell quiescence, though the mechanism...

Bryce C. Murillo, Alexander P. Young, Kaitlyn Wintruba et al. · JCI Insight · 0 citations

Open access Aug 2026

Small-Molecule-Mediated Depletion of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1B (DYRK1B) Protein Scaffold

Members of the DYRK kinase family have been implicated in the regulation of key metabolic processes. In particular, DYRK1B plays a central role in hepatic lipid metabolism and fatty liver disease. Notably, these functions depend not only on the enzyme’s catalytic activity but also on scaffolding properties. Consequentl...

Miriam S. Ems, Mattias F. Lindberg, Till Adhikary et al. · ACS Pharmacology & Translati... · 0 citations