Open access
Sep 2026
Native Hydrogen/Deuterium Exchange Ion Mobility Mass Spectrometry of Structured DNA Oligonucleotides
IMS is established as an essential tool for complementing HDX/MS in the characterization of structural polymorphism and conformational ensembles in DNA oligonucleotides and can be leveraged to distinguish groups of non-specific cation binding on a given conformational ensemble.
Matthieu Ranz, Romane Guisiano, Eric Largy et al.
· bioRxiv · 0 citations