Author

Matthias Mann

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Open access Oct 2026

SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.

Forward genetic screening links genotype to phenotype by introducing random genetic perturbations and identifying phenotype-altering mutations. Although genome-scale screens are routine for simple phenotypes in cultured cells, extending them to complex image-based phenotypes remains challenging. Here, we present spatia...

Niklas A. Schmacke, Sophia C. Mädler, G. Wallmann et al. · Cell · 0 citations

Open access Oct 2026

Conserved mycobacteriophage protein uses structural mimicry to displace host initiation factors

Compact viral genomes encode sophisticated strategies to reprogram host gene expression, often by co-opting rather than replacing RNA polymerase. How bacteriophages achieve such control in Mycobacteria remains largely unknown. Here, time-resolved interaction proteomics of mycobacteriophage D29 infection identifies a co...

David R. Parker, Shrestha Ghosh, Adela Dujiskova et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

In the same cell, the proteome defines cellular state and the transcriptome marks transitions

A scalable technology is introduced that quantifies thousands of proteins and transcripts in the same cell, separating RNA from protein by tip-based C18 capture and pairing full-length RNA sequencing with latest-generation mass spectrometry to yield deep proteome and transcriptome from the same cells.

M. Thielert, Enes Ugur, Maximilian Zwiebel et al. · bioRxiv · 1 citation