Author

Matthew T. Birnie

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Open access Oct 2026

Peptide signaling in the paraventricular thalamus is essential for disrupted adult reward behaviors consequent to early-life adversity.

Early-life adversity (ELA) is strongly linked to emotional disorders characterized by dysregulated reward behaviors. However, the mechanisms by which transient neonatal experiences generate enduring, sex-specific alterations in brain function remain unresolved. Paraventricular thalamus (PVT) neurons are selectively act...

A. Floriou-Servou, Ryan Weber, Yun-Cai Chen et al. · Cell Reports · 0 citations

Open access Aug 2026

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stress

It is found CRH signaling via CRHR1 indeed disrupts reward behaviors in naïve mice, but is dysregulated in ‘anhedonic’ mice with a history of ELA, and activation of CRH receptor 2 (CRHR2) reverses anhedonia-like behaviors in adult ELA mice.

Matthew T. Birnie, Lara Taniguchi, Lia M. Harvey et al. · bioRxiv · 0 citations