Engineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation
Messenger RNA (mRNA) therapeutics have transformed vaccination and protein replacement strategies, yet efforts to improve their performance have focused largely on sequence engineering, nucleotide modification, and delivery vehicles. Here we show that mRNA function can be controlled by rational design of higher-order R...
Mark D. Knappenberger, S. J. Henry, Archana Kikla et al.
· bioRxiv · 0 citations