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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Matthew R Allen

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Open access Aug 2026

Combining dietary fiber inulin with parathyroid hormone-lowering therapy improves bone remodeling and mechanics in a rat model of Chronic Kidney Disease-Mineral Bone Disorder.

INTRODUCTION Chronic kidney disease (CKD) has devastating effects on the skeletal system resulting in an increased fracture risk. CKD results in the buildup of metabolites in the blood (often referred to as uremic toxins), and several uremic toxins have been linked to adverse skeletal outcomes. We have shown that dieta...

M. R. Allen, Corinne E. Metzger, Neal X. Chen et al. · 0 citations
Open access Jul 2026

Four weeks of romosozumab treatment increases trabecular bone volume and differentially improves cortical bone in young and aging mice with chronic kidney disease

Chronic kidney disease (CKD) leads to significant bone loss and high risk of fractures. Fractures are even more prevalent in the aging population with CKD. Cortical bone is particularly impacted in CKD due to cortical thinning and the development of cortical porosity. The goal of this study was to assess the impact of...

Corinne E. Metzger, Allison R Kolhouse, Joana Santamaria Vilchis et al. · 0 citations

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