Author

Matthew P. Padula

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Open access Oct 2026

Integrated Top-Down Proteomics for Comprehensive Proteome Analysis at the Proteoform Level

Background: Proteoforms are the critical functional species that drive biological processes. However, conventional proteogenomic (“shotgun”) analyses discard relevant proteoform-level information through bulk protein digestion. This study presents a proof-of-principle integrative Top-Down Proteomics workflow designed t...

Luke A. Farrell, Breyer Woodland, A. Brennan et al. · Proteomes · 0 citations