Open access
Oct 2026
Structural and kinetic basis of serine mono-ADP-ribosylation reversal by human ADP-ribosyl-acceptor hydrolase 3.
Serine MARylation (Ser-MARylation), catalyzed by poly(ADP-ribose) polymerase 1/2 (PARP1/2)-Histone PARylation factor 1 (HPF1) complex and reversed by ADP-ribosyl-acceptor hydrolase 3 (ARH3), is the primary form of DNA damage-induced ADP-ribosylation in human cells. Distinct from PARylation, Ser-MARylation represents a...
Prem Shrestha, Sharon Lin, Ainsley Lederer et al.
· Journal of Biological Chemis... · 0 citations