Author

Matthew D. Wilkerson

2 papers indexed here

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Sep 2026

Abstract B141: Anti-Lymphocyte Antigen 6D (LY6D) monoclonal antibody inhibits pancreatic tumor growth in vivo by downregulating the TGFb-Smad2 signaling

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the United States and is associated with dismal prognosis. Recent studies revealed that LY6D expression is elevated in PDAC and correlates with poor patient survival. However, the functional role of LY6D in PDAC progressio...

Yong-chul Kim, Deepak Rohilla, David J. Wisniewski et al. · Cancer Research · 0 citations

Open access Sep 2026

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity

It is found that the requirement for wild-type RAS to support mutant NRAS–driven transformation correlated with codon-specific differences in GTP hydrolysis, which defines the signaling partnership between mutant NRAS and wild-type HRAS as a targetable vulnerability and provides a biochemical blueprint for dual RAS inh...

Hyun Lee, Jacob M. Hughes, Joseph P. LaMorte et al. · Science Signaling · 0 citations