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Author

Matthew D. Smith

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Open access Sep 2026

Intracellular complement factor H protects neurons during CNS inflammation

Using single-nucleus RNA-sequencing analysis of RGCs from donors with MS and control individuals, it is found that CFH expression was strongly correlated with intrinsic resilience to RGC degeneration and reveals a non-canonical intracellular function of CFH in neurons.

Christina Mayer, Marcel S. Woo, J. Sonner et al. · 0 citations
Open access Aug 2026

Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination

It is shown that inflammation reprograms OPC lipid metabolism, linking altered metabolism to remyelination failure and highlighting LXR activation as a therapeutic approach to enhance remyelination in multiple sclerosis.

Judy J Lee, Matthew D. Smith, Xiaojing Deng et al. · 0 citations

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