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Author

Matthew D. Mann

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Open access Mar 2025

Nucleosome Engagement Regulates RORγt Structure and Dynamics

RORγt is a key transcriptional regulator that supports protective pathogen clearance but also drives autoimmune disorders. Genetic studies have identified RORγt mutations that selectively protect from autoimmunity without compromising host defense. Herein, we describe the molecular principles governing how RORγt select...

Timothy S. Strutzenberg, Xian-Du Li, Matthew D. Mann et al. · 0 citations
Open access Jul 2026

Discovery of low molecular weight protein-binding fragments from bead-displayed libraries: application to monomeric proteins

Various strategies to multimerize monomeric targets are explored, thus allowing them to be used as targets in this fragment discovery platform and a particularly effective and convenient strategy is to express a fusion of the POI with FOLDON, a 30-residue, homo-trimeric peptide.

Joel Tong, Isuru M. Jayalath, James V. Parsons et al. · 0 citations
Open access Jul 2026

Rational design of RORγT small molecule modulators results in tunable LXRα pleiotropic effects in Th17 cells 2267479

Rational design of small molecule modulators enhanced RORγT inverse agonism and tuned LXRα agonism enhanced RORγT inverse agonism and tuned LXRα agonism better suppressed the pathogenic Th17 phenotype, reducing IL-17 secretion and downstream gene expression.

Matthew D. Mann, Mi-Ra Chang, Vuong Q. Dang et al. · 0 citations

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