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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Matteo De Leonardis

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Open access Sep 2026

Modeling Protein Sequence Evolution as an Ornstein-Uhlenbeck Process in a Latent Space

An unsupervised inference model that integrates directed-evolution sequencing time series with natural homologs is presented and the inferred couplings improve structural contact prediction by combining global evolutionary constraints from nature with local, experiment-specific signals.

Matteo De Leonardis, Andrea Pagnani · 0 citations

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