Bispecific antibodies that engage pIgR enrich in mucosa in cynomolgus monkeys.
It is shown that pIgR-targeted bispecific antibodies rapidly deplete from serum, while enriching 5-10-fold in bronchoalveolar lavage fluid compared to normal IgG antibodies, which support the use of anti-pIgR bispecific antibodies to treat diseases requiring targeting in mucosal areas.
Kelsie Marks, Nirav Shah, L. Phạm et al.
· mAbs · 0 citations