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Author

M. Clement

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Open access Apr 2025

Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice

Using transgenic 3xTg-AD mice, systemic infection with the β-herpesvirus murine cytomegalovirus (MCMV) accelerates the development of cognitive decline, tauopathy, and synaptic loss in the hippocampus, all of which are key features of AD.

M. Marsden, J. E. McLaren, Ryan J. Bevan et al. · 3 citations
Open access Jul 2026

Cytomegalovirus-induced T cell responses accelerate Alzheimer's disease progression in mice.

Infections have long been implicated as causative factors in Alzheimer's disease (AD). Multiple studies have further suggested a key role for herpesviruses, such as cytomegalovirus (CMV). Using transgenic 3xTg-AD mice, we demonstrate that systemic infection with the β-herpesvirus murine CMV (MCMV) accelerates the devel...

M. Marsden, J. McLaren, Ryan J Bevan et al. · 0 citations

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