Masaya Matsuda

Pathogenic group 2 innate lymphoid cells as drivers of lung fibrosis in severe asthma

Severe asthma is characterized by persistent airway inflammation, irreversible airway remodeling, and reduced responsiveness to glucocorticoids. Subepithelial fibrosis, a major determinant of progressive lung function decline, remains mechanistically undefined. Evidence identifies group 2 innate lymphoid cells (ILC2s)...