Open access
Jul 2026
PhiKan 083 Inhibits MYCN Expression in Liver Cancer Cells Independent of p53 Pathways.
Findings suggest that PK83 suppresses MYCN expression and preferentially affects MYCN-high HCC cells in a p53-independent manner, warranting further preclinical investigation of PK83 and related compounds in MYCN-associated cancers.
Ya-Li Xu, Hricha Mishra, Masataka Takahashi et al.
· ACS Pharmacology & Translati... · 0 citations