Enzyme-Guided Classification of Fungal Eremophilane Biosynthetic Gene Clusters Provides a Predictive Framework for Structural Diversity
Elucidating how oxidative tailoring enzymes generate structural diversity in natural products remains a major challenge, because their functions are difficult to predict directly from sequence information. Fungal eremophilanes (EMPs), which share a conserved bicyclic core yet exhibit extensive oxidative diversificati...