Open access
Sep 2026
Combinatorial action of regulatory systems generates colistin heteroresistance
The sigma factor σE is identified as the source of heterogeneity in colistin resistance and the combinatorial action of regulatory systems, encompassing a heterogeneity generator and a distinct resistance generator, gives rise to colistin heteroresistance.
Jacob E. Choby, E. Crispell, Mu-Qing Ma et al.
· Science Advances · 0 citations