Jul 2026
Psoriasis-risk SNP rs610604 reveals nuclear IKKα-TNFAIP3 repressor axis driving autoinflammatory circuits.
A nuclear IKKα-TNFAIP3 axis linking genetic susceptibility to inflammatory signaling is identified, providing a potential explanation for the paradox of chronic inflammation without frequent malignant transformation in psoriatic skin, and highlighting IKKα as a potential therapeutic target in psoriasis and related infl...
Maria Benedetta Rizzarda Maffezzoni, F. Moretti, E. Botti et al.
· Journal of Investigative Der... · 0 citations