Background: Novel Synthetic Opioids (NSOs) currently represent the third most prevalent group among New Psychoactive Substances (NPS), yet they represent the category associated with the highest health risk. Their extreme pharmacological potency compared to traditional opioids, coupled with structural heterogeneity and...
Ilenia Bracaglia, Ludovica Chiodo, C. Montesano et al.· Metabolites· 0 citations
Synthetic cathinones are one of the most prevalent new psychoactive substances on the drug market over the last 20 years. Their structural diversity, rapid turnover and variable stability in biological matrices pose significant challenges for laboratories. This study applied a comprehensive, multi-analytical workflow t...
Sara Odoardi, Serena Mestria, Giulia Biosa et al.· Analytical and Bioanalytical...· 0 citations
Fentanyl analogues, including butyrylfentanyl (BUF) and 4-fluorobutyrylfentanyl (4F-BUF), are increasingly implicated in severe toxicity and fatal overdoses. While their pharmacological activity at µ-opioid receptors is well established, the cellular mechanisms underlying their neurotoxic effects remain incompletely un...
D. Ratto, S. Bilel, Francesca Dalle Sasse et al.· Archives of Toxicology· 1 citation
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