Author

Marleen M. Kock

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Open access Sep 2026

Genomics of multidrug-resistant Klebsiella pneumoniae isolates from community hospitals in Pretoria, South Africa

Highlights • The sequence type 307 clone is highly prevalent in South African hospitals.• Pandrug ST307 high-risk clone with three carbapenemases is a public health threat.• Emerging double-carbapenemase producers reduce available treatment options.• Diverse plasmids drive antibiotic resistance in Klebsiella pneumoniae...

Mokawane Victor Mohlamoyane, J. Pitout, T. Lentswe et al. · IJID Regions · 0 citations

Review Open access Sep 2026

Escherichia coli with penicillin-binding protein 3 insertions: implications for newer β-lactam/β-lactamase inhibitor combinations

ABSTRACT Escherichia coli with penicillin-binding protein 3 (PBP3) insertions appeared in the early 2000s and expanded during the 2010s. The YRIN and YRIK variants predominate globally, while other insertion types remain rare. These insertions frequently co-occur with carbapenemases (NDM-5 and OXA-181) and high-risk cl...

Johann D. D. Pitout, G. Peirano, Y. Matsumura et al. · Antimicrobial Agents and Che... · 0 citations